Name: Dr. Rajesh Sonti Associate professor rajesh.sonti@niperhyd.ac.in +91 40 23074750 Extn- 2025 +91-040-23074750 (Ext. No: 2013) My Citations Full Profile (pdf)

ADDRESS, ROOM NO

Department of Pharmaceutical Analysis
Room no: 51
NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA

QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

• 03/2018 - Project management training based on IPMA standards, SPOL AG training center, Steinhausen, Switzerland
• 06/2015 - 06/2017 - DAS in European Centre of Pharmaceutical Medicine, University of Basel, Switzerland
• 06/2017 - GCP Training for Investigators and Study Teams, University of Basel, Switzerland
• 08/2008 - 10/2013 - PhD Chemical Biology, Prof. P. Balaram, Indian Institute of Science - Bangalore, India
• 06/2006 - 05/2008 - Masters in Chemistry, Sri Sathya Sai University - A.P, India
• 06/2003 - 05/2006 - B.Sc (Hons.) in Chemistry, Sri Sathya Sai University - A.P, India

EXPERIENCE

• 02/2020 - Present : Working as Assistant Professor at NIPER, Hyderabad.
• 11/2018 - 02/2020 : Collaborative Scientist, Prof. R. Gruetter, CIBM - EPFL, Lausanne, Switzerland
• 11/2013 - 10/2018 : Postdoctoral fellow under Prof. S. Grzesiek, Biozentrum – Basel, Switzerland .

COURSES HANDLING(PHD/M.PHARM)

M.S (Pharm):
PA-510: Topics in Pharmaceutical Analysis
PA-610: Pharmacopoeial Methods of Analysis
PA-620:Modern Instrumental Techniques for Evaluation of APIs and Drug Products.

PhD:
PA-730: CE and SFC in Pharmaceutical Analysis
PA-760: Mass spectrometry in Pharmaceutical Analysis

PHD STUDENTS/MASTERS STUDENTS

Masters: Guided: 17 ; Ongoing - 7 [Advisor]
Ph.D: Ongoing - 4 [Advisor]
SERB JRF: Ongoing - 1

AWARDS / HONOURS

1. Recipient of partial travel grant from University of Basel for 58th ENC held at Asilomar, CA, USA
2. Selected for the EMBO 2013 travel grant of practical course on “Structure, dynamics and function of biomacromolecules"
3. Recipient of ICMRBS student travel Grant for XXVth ICMRBS 2012 held at Lyon, France.
4. Selected for the CSIR travel grant for XXVth ICMRBS 2012 held at Lyon, France.
5. Selected for the CICS-INSA travel grant for XXVth ICMRBS 2012 held at Lyon, France.
6. Recipient of ENC student travel award for ENC2011 held at Asilomar, CA, USA.
7. Selected for the DST travel grant for ENC2011 held at Asilomar, CA, USA.
8. Recipient of NMRS travel award for ENC2011 held at Asilomar, CA, USA.
9. Qualified in the All India Gate 2007.
10. Selected for summer internship at GE (SABIC –Plastics) analytical division in 2008.

RESEARCH AREAS/INTEREST

During his Ph.D. at IISC-Bangalore with Prof. P. Balaram, he has worked on designed and natural peptides that are hybrid beta-sheets, modified alpha-helices, and cyclic disulfide-bonded peptides. He has done the conformational analysis of several peptides and solved 23 structures of peptides by solution NMR. In Biozentrum, Basel-Switzerland, he worked with the protein, Abelson tyrosine kinase involved in Chronic Myeloid Leukemia in the group of Prof. Stephan Grzesiek. He tested the interaction of FDA-approved drugs, e.g., Gleevec (Novartis), Tasigna (Novartis), Sprycel (Bristol-Myers Squibb), Iclusig (ARIAD Pharmaceuticals), and Inlyta (Pfizer) that bind at the ATP binding site in a solution using NMR spectroscopy. These studies lead to the identification mechanism of Abl disassembled state upon binding of certain drugs from the assembled state. He characterized activities of several drug resistant mutants (‘gatekeeper,’ completely activated P242E/P249E), assessed their conformations, probed interdomain dynamics by 15N relaxation studies. At EPFL Laussane-Switzerland in the group of Prof. Rolf Gruetter, worked on the determination of lactate concentrations in the mice plasma and analyzed the fragmental labelling, 13C isotope enrichment by NMR. Furthermore, he worked on determining the concentrations of metabolites in mice cortex, hippocampus, and striatum regions using in vivo 9T MRS magnet. Further, European Centre of Pharmaceutical Medicine (ECPM-DAS) course at the University of Basel enhanced my knowledge and understanding of pharmaceutical medicine. With the best training and world-class experience received, he has started his career at NIPER-Hyderabad.

The scientific goal of my research is the application of analytical techniques such as Nuclear Magnetic Resonance (NMR), High resolution mass spectrometry (HRMS) for the elucidation of structure, and dynamics of peptides with a particular emphasis on understanding conformational diversity of novel conopeptides as a core area. The group is also interested in drug-drug interactions, metabolism of herbal drugs and drug stability studies. We collaborate with several scientists and provide analytical support in NIPER and outside. Further, we actively engage in consultancy projects for the structure elucidation of APIs and higher-order structure determination of biosimilars for pharmaceutical companies.

GRANTS/FELLOWSHIPS

1. CCRUM project on “Structural characterization, pharmacokinetics, pharmacodynamic and herb-drug interactions of major constituents of compound Unani formulation for diabetes” awarded on 25 Apr 2024 - INR 28.17 Lakhs.
2. DBT project “Therapeutic leads for pain from Conus peptides of Indian marine coast” awarded on 09 Nov 2023 - INR 89.58 Lakhs.
3. DST SERB SRG awarded in December 2021 - INR 27 Lakhs.
4. Co-recipient of Swiss Cancer League grant of three years in 2014, Biozentrum, University of Basel, Switzerland.
5. Awarded CSIR Junior Research Fellowship Dec 2007 and Senior Research Fellowship in Aug 2010.

PUBLICATIONS / BOOK CHAPTERS

1. Harshada Anil Bhalerao., Pooja Dhurjad., Anish Bharate., Rajesh Sonti. Journal of Pharmaceutical and Biomedical Analysis, 2026, 280,117622.
   A single bioanalytical LC-MS/MS method for the quantification of pelitinib across biological matrices: An insight into in vitro metabolic stability, in vivo pharmacokinetics
   https://doi.org/10.1016/j.jpba.2026.117622
2. Rati Yadav., Padakanti Sandeep Chary., Harshada Anil Bhalerao., Rajesh Sonti.,* Neelesh Kumar Mehra*. Annales Pharmaceutiques Francaises, 2026.
   Development, validation and application of LC-MS/MS method for simultaneous determination of irinotecan and cyclosporine in co-loaded self-nanoemulsifying drug delivery system
   https://doi.org/10.1016/j.pharma.2026.05.007
3. Talari, S.; Nelwade, P. T.; Sonti, R.. Journal of Molecular Structure, 2026, 1366, 146071.
   Isolation and structural characterisation of the degradation products of tazemetostat hydrobromide, an FDA-approved EZH2 inhibitor: Evidence for two distinct N-oxidation pathways
   https://doi.org/10.1016/j.molstruc.2026.146071
4. Shweta Dhannura, Marimuthu Vijayasarathy, Kashibai Patil, Bharathi Manjunath, Rajesh Sonti, Prasanna D Revanasiddappa, Konkallu Hanumae Gowd. Journal of Biomolecular Structure and Dynamics, 2026, 1-21.
   Site-specific post-translational modifications regulate the binding affinity of conus amadis α-conotoxin Am2005 to Ac-AChBP
   https://doi.org/10.1080/07391102.2026.2648676
5. Reddy, G. N.; Gottimukkula, B. R.; Bhalerao, H. A.; Talari, K.; Sonti, R.. Food and Chemical Toxicology, 2025, 206, 115761.
   Metabolite identification of ripretinib by UPLC-ESI-MS/MS: in silico prediction, in vitro metabolism, and stability assessment
   https://doi.org/10.1016/j.fct.2025.115761
6. Reddy, G. N.; Palepu, M. S. K.; Sonti R*. RSC Analytical methods, 2025, 17, 9565.
   LC-MS/MS-based investigation of pharmacokinetic interactions between CYP3A4 substrates enzalutamide and repaglinide in rats
   https://doi.org/10.1039/d5ay01451d
7. Dhurjad, P.; Bazaz, R.; Pati, S.; Dandekar, M. P.; Godugu, C.; Sonti R*. RSC Medicinal Chemistry, 2025, 16, 4106.
   Structure and activity of conopressins: Insights into in silico oxytocin/V2 receptor interactions, anti- inflammatory potential, and behavioural studies
   https://doi.org/10.1039/d5md00288e
8. Anuradha Singampalli, Rani Bandela, Bulti Bakchi, Sarvan Maddipatla, Pardeep Kumar, Sri Mounika Bellapukonda, Puja Kumari Agnivesh, Kishan Kumar Parida, Simone Giovannuzzi, Karol Biernacki, Alessandro Bonardi, Paola Gratteri, Harshada Anil Bhalerao, Rajesh Sonti, Srinivas Nanduri, Claudiu T Supuran, Nitin Pal Kalia, Madhavi Venkata Yaddanapudi ; Journal of Medicinal Chemistry; 2025. 18370-18388, 68.
   Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and In Silico Studies- An In-Depth Multidisciplinary Study
   https://doi.org/10.1021/acs.jmedchem.5c01026
9. Dhurjad, P.; Dannarm, S. R.; Shaik, K.; Wanjari, P.; Sonti, R.. ACS Omega, 2025,10, 54030.
   Conformational heterogeneity of Pro-Pro containing 23-membered ring conopeptides by NMR
   https://doi.org/10.1021/acsomega.5c05404
10. Radhakrishna Krishnappa, Sougata Shit, Priyanka Dey, Abhishek Nayak, Deepak Kumar Sahoo, Khajapeer Shaik, Rajesh Sonti, Srinivasarao Raghothama, Konkallu Hanumae Gowd; ACS omega, 2025, 50139-50152, 10.
    Comparative Study of UVA Filtering Compounds 2-Methyl/2-Amino Pyrimidine Derivatives of Avobenzone under Acidic Conditions
    https://doi.org/10.1021/acsomega.5c06701
11. Yadav, R.; Chary, P. K.; Bhalerao, H.; Srivastava, V.; Pardhi, E.; Pawar, A.; Sonti R.; Mehra, N. K. ACS Applied Bio Materials, 2025, 8, 5883.
    Nanotechnology-Driven Colorectal Cancer Treatment: Coencapsulation of Irinotecan and Cyclosporine A in SNEDDS for Superior Outcomes
    https://doi.org/10.1021/acsabm.5c00567
12. Ojaswitha Ommi, Harshada Anil Bhalerao, Pradip Malik, Juned Ali, Deepanshi Saxena, Srinivas Nanduri, Rajesh Sonti, Arunava Dasgupta, Sidharth Chopra, Venkata Madhavi Yaddanapudi, 2025, Bioorganic & Medicinal Chemistry, 118341,129.
    Synthesis of 1,3-diaryl substituted pyrazole-based imidazo [1,2-a] pyridine carboxamides and evaluation of their antitubercular activity
    https://doi.org/10.1016/j.bmc.2025.118341
13. Dannarm, S. R.; Gottimukkula, B. R.; Dhalaram, C. S.; Reddy, G. N.; Sonti, R.. Microchemical Journal, 2025, 214, 113885.
    Environmental degradation of the anticancer drug encorafenib: Evidence for cyclisation through aromatic ring flip under photolytic conditions
    https://doi.org/10.1016/j.microc.2025.113885
14. Dandekar, M. P.; Guin, S.; Sammeta, S.; Saha, C.; Bhalerao, H. A.; Sonti, R. Journal of Ayurveda and Integrative Medicine, 2025, 16, 101131.
    Polyherbal formulation mitigates age-associated cognitive deficits in rats
    https://doi.org/10.1016/j.jaim.2025.101131
15. Gajula, S. N. R.; Munjal, V.; Talari, S.; Rahman, Z.; Dandekar, M. P.; Sonti, R.. Biopharmaceutics & Drug Disposition, 2025, 46, 67.
    The Influence of a Rat Model of Depression and Gastric Ulcer on the Pharmacokinetics of Encorafenib
    https://doi.org/10.1002/bdd.70006
16. Sahoo, D. K.; Nayak, A.; Dannarm, S. R.; Jahnavi, A. S.; Dikundwar, A. G.; Sonti, R.; Gowd, K. H. Journal of Photochemistry and Photobiology A: Chemistry, 2025, 459, 116099.
    Pyrimidine derivative mimicking the locked enol form of avobenzone acts as a photostable UVAII and UVB filter
    https://doi.org/10.1016/j.jphotochem.2024.116099
17. Maddipatla, S.; Bakchi, B.; Shinde, M. A.; Bonardi, A.; Raman, P. K.; Bhalerao, H. A.; Singampalli, A.; Nanduri, S.; Godugu, C.; Sonti, R.; Supuran, C. T. Archiv der Pharmazie., 2025, 358(1), e2400482.
    New 7‐hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies
    https://doi.org/10.1002/ardp.202400482
18. Palepu, M. S. K.; Bhalerao, H. A.; Sonti, R.; Dandekar, M. P. European Journal of Pharmacology, 2024, 983,176960.
    Faecalibacterium prausnitzii, FOS and GOS loaded synbiotic reverses treatment-resistant depression in rats: Restoration of gut-brain crosstalk
    https://doi.org/10.1016/j.ejphar.2024.176960
19. Shekh, S.; Dhannura, S.; Dhurjad, P.; Ravali, C.; Spoorti, M. M.; Kakkat, S.; Vijayasarathy, M.; Sonti, R.; Gowd. K. H. ​ Toxicon, 2024, 250, 108087.
    Structure-aided function assignment to the transcriptomic conopeptide Am931
    https://doi.org/10.1016/j.toxicon.2024.108087
20. Dhannura, S.; Shekh, S.; Dhurjad, P.; Dolle, A.; Kakkat, S.; Vishwajyoth; Vijayasarathy, M.; Sonti, R.; Gowd K. H. ACS omega, 2024, 9, 36.
    Redox-Active Conopeptide Li520 Has Evolved to Catalyze Oxidative Folding of Conotoxins
    https://doi.org/10.1021/acsomega.4c01028
21. Reddy, G. N.; Jogvanshi, A.; Reddy, D. S.; Chenkual, L.; Sonti, R.. Bioanalysis, 2024, 8, 1.
    DoE-assisted HPLC method development and validation of enzalutamide and repaglinide in rat plasma
    https://doi.org/10.1080/17576180.2024.2383070
22. Dannarm S. R.; Kalan, P.; Ganta, B.; Reddy, G. N.; Sonti, R. Journal of Environmental Chemical Engineering, 2024, 12, 114111.
    Study on hydrolytic, oxidative and photolytic degradation behaviour of anticancer drug sonidegib: Characterization of the products by UHPLC-Q-TOF-MS/MS, 2D NMR and in silico toxicity assessment
    https://doi.org/10.1016/j.jece.2024.114111
23. Sen, S.; Ganta, B.; Rachel, V. N.; Gogikar, S. K.; Singh, V.; Sonti, R.; Dikundwar, A. G. Journal of Pharmaceutical Sciences, 2024, 113, 2028.
    Mapping Advantages and Challenges in Analytical Development for Fixed Dose Combination Products, a Review
    https://doi.org/10.1016/j.xphs.2024.04.025
24. Yadav, R.; Bhawale, R.; Srivastava, V.; Pardhi, E.; Bhalerao, H. A.; Sonti, R.; Mehra, N. K. AAPS PharmSciTech., 2024, 25, 52.
    Innovative Nanoparticulate Strategies in Colon Cancer Treatment: A Paradigm Shift
    https://doi.org/10.1016/j.xphs.2024.04.025
25. Palepu, M. S. K.; Gajula, S. N. R.; Malleshwari, K.; Sonti, R.; Dandekar, M. P. ACS Chemical Neuroscience, 2024, 15, 1010.
    SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats
    https://doi.org/10.1021/acschemneuro.3c00727
26. Paladini, J.; Maier, A.; Habazettl; Judith, M.; Hertel, I.; Sonti, R.; Grzesiek, S. eLife, 2024.
    The molecular basis of Abelson kinase regulation by its αI-helix
    https://doi.org/10.1101/2023.10.04.560671
27. Dannarm, R. S.; Dharipally, H.; Reddy, G. N.; Ali, N.; Sonti, R.. Journal of Pharmaceutical and Biomedical Analysis, 2024, 239, 115909.
    Study on the hydrolytic degradation behaviour of bictegravir by LC-PDA-Q/TOF-MS/MS NMR and in silico toxicity assessment
    https://doi.org/10.1016/j.jpba.2023.115909
28. Ommi, O.; Chilvery, S.; Dhopat, P. S.; Sharma, A.; Bhalerao, H. A.; Dannaram, S. R.; Nanduri, S.; Sonti, R.; Godugu, C.; Yaddanapudi, V. M. Journal of Molecular Structure, 2023, 1292, 136184.
    Exploration of quinoxaline-benzimidazole hybrids as apoptosis-inducing agents and tubulin polymerisation inhibitors
    https://doi.org/10.1016/j.molstruc.2023.136184
29. Ojaswitha; Paoletti, N.; Bonardi, A.; Gratteri, P.; Bhalerao, H. A.; Sau, S.; Nanduri, S.; Mohammed, A.; Kalia, N. P.; Sonti, R.; Yaddanapudi,V. M. Archiv der Pharmazie., 2023, 356, 2300309.
    Exploration of 3‐aryl pyrazole‐tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors
    https://doi.org/10.1002/ardp.202300309
30. Dhurjad, P.; Gupta, K.; Sakla, A. P.; Shankaraiah, N.; Sonti, R.. Separation Science Plus, 2023, 6, 2300073.
    A validated high‐performance liquid chromatography method for the determination of brassinin, an indoleamine 2, 3‐dioxygenase inhibitor in rat plasma
    https://doi.org/10.1002/sscp.202300073
31. Shekh, S.; Dhurjad, P.; Vijayasarathy, M.; Dolle, A.; Dhannura, S.; Sahoo, D. K.; Sonti, R.; Gowd, K. H. Biochemistry, 2023, 62, 3061.
    Oxidative Folding Catalysts of Conotoxins Derived from the Venom Duct Transcriptome of C. frigidus and C. amadis
    https://doi.org/10.1021/acs.biochem.3c00320
32. Reddy, G. N.; Jogvanshi, A.; Naikwadi, S.; Sonti, R.. Expert Review of Anti-infective Therapy, 2023, 21, 943.
    Nirmatrelvir and ritonavir combination: an antiviral therapy for COVID-19
    https://doi.org/10.1080/14787210.2023.2241638
33. Yakkala, P. A.; Khan, I. A.; Dannarm, S. R.; Aboti, J.; Sonti, R.; Shafi, S.; Kamal, A. The Journal of Organic Chemistry, 2023, 88, 12216.
    Multicomponent Domino Reaction for Concise Access to 2-Amino-Substituted 1, 3, 4 Oxadiazoles via Smiles Rearrangement
    https://doi.org/10.1021/acs.joc.3c00516
34. Gajula, S. N. R.; Talari, S.; Nathani, T. N.; Munjal, V.; Rahman, Z.; Dandekar, M. P.; Sonti, R.. Bioanalysis, 2023, 15, 695.
    Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten
    https://doi.org/10.4155/bio-2023-0030
35. Gajula, S. N. R.; Godugu, C.; Sonti, R.. Bioanalysis, 2023.
    Chronopharmacokinetics: a critical missing step in drug discovery and development
    https://doi.org/10.4155/bio-2023-0080
36. Gajula, S. N. R.; Talari, S.; Chilvery, S.; Godugu, C.; Sonti, R.. RPS Pharmacy and Pharmacology Reports, 2023, 2, 2.
    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
    https://doi.org/10.1093/rpsppr/rqad017
37. Rao Gajula, S. N.; Khairnar, A. S.; Jock, P.; Kumari, N.; Pratima, K.; Munjal, V.; Kalan, P.; Sonti, R.. Expert Review of Proteomics, 2023, 1.
    LC-MS/MS: A sensitive and selective analytical technique to detect COVID-19 protein biomarkers in the early disease stage
    https://doi.org/10.1080/14789450.2023.2191845
38. Dhurjad, P.; Jaiswal, P.; Gupta, K.; Wanjari, P.; Sonti, R.. Separation Science Plus, 2023, 6.
    Mass spectrometry: A key tool in anti‐doping
    https://doi.org/10.1002/sscp.202200058
39. Sana, S.; Dannarm, S. R.; Tokala, R.; Dastari, S.; Sathish, M.; Kumar, R.; Sonti, R.; Shankaraiah, N. Organic Chemistry Frontiers, 2023, 10, 4800.
    Sustainable photocatalytic C–H annulation of heteroarenes with sulfoxonium ylides: synthesis and photophysical properties of fused imidazo [1, 2-a] pyridine-based molecules
    https://doi.org/10.1039/d3qo00923h
40. Sana, S.; Dastari, S.; Dannarm S. R.; Tokala, R.; Sathish, M.; Sonti, R.; Shankaraiah, N. Organic Chemistry Frontiers, 2023, 10, 4573.
    Visible-light-mediated photocatalytic sequential N-arylation: an eco-friendly synthetic route to unsymmetrical diarylamines and the imatinib drug
    https://doi.org/10.1039/d3qo00894k
41. Ommi, O.; Ahmad, M. N.; Gajula, S. N. R.; Wanjari, P.; Sau, S.; Agnivesh, P. K.; Sahoo, S.K.; Kalia, N. K.; Sonti R.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. RSC Medicinal Chemistry, 2023, 14, 1296.
    Synthesis and pharmacological evaluation of 1, 3-diaryl substituted pyrazole based (thio) urea derivatives as potent antimicrobial agents against multi-drug resistant Staphylococcus aureus and Mycobacterium tuberculosis
    https://doi.org/10.1039/d3md00079f
42. Makhal, P. N., Dannarm, S. R.; Shaikh, A. S.; Ahmed, R.; Chilvery, S.; Dayare, L. N.; Sonti, R.; Godugu, C.; Kaki, V. R. Chemical Communications, 2023, 59, 3767.
    Exo-trig selenocyclization of secondary allylic carboxamides using Woollins’ reagent: en route to 2, 5-disubstituted selenazolines
    https://doi.org/10.1039/d2cc06782j
43. Satti, S.; Palepu, M. S. K.; Singh, A. A.; Jaiswal, Y.; Dash, S. P.; Gajula, S. N. R.; Chaganti, S.; Samanthula, G.; Sonti, R.; Dandekar, M. P. Neurochemistry International, 2023.
    Anxiolytic-and antidepressant-like effects of Bacillus coagulans Unique IS-2 mediate via reshaping of microbiome gut-brain axis in rats
    https://doi.org/10.1016/j.neuint.2023.105483
44. Kushwah, B. S.; Padhy, H. P.; Khemchandani, R.; Golla, V. M.; Kanchupalli, V. K.; Sonti, R..; Samanthula, G. Journal of Pharmaceutical and Biomedical Analysis, 2022, 221, 115077.
    Structural characterization of novel hydrolytic and oxidative degradation products of acalabrutinib by LC-Q-TOF-MS, H/D exchange and NMR
    https://doi.org/10.1016/j.jpba.2022.115077
45. Gajula, S. N. R.; Nathani, T. N.; Patil, R. M.; Talari, S.; Sonti, R.. Drug Metabolism Reviews, 2022, 54, 427.
    Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development
    https://doi.org/10.1080/03602532.2022.2144879
46. Dhurjad, P.; Dhalaram, C. S.; Ali, N.; Kumari, N.; Sonti, R.. Chirality, 2022, 34, 1419-1436.
    Metal-organic frameworks in chiral separation of pharmaceuticals
    https://doi.org/10.1002/chir.23499
47. Sahoo, S. K.; Gajula, S. N. R.; Ahmad, M. N.; Kaul, G.; Nanduri, S.; Sonti, R.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Archiv der Pharmazie., 2022, 11, 2200168.
    Bioevaluation of quinoline‐4‐carbonyl derivatives of piperazinyl‐benzothiazinones as promising antimycobacterial agents
    https://doi.org/10.1002/ardp.202200168
48. Gajula, S. N. R.; Vora, S. A.; Dikundwar, A. G.; Sonti, R.. IntechOpen, 2022.
    In Vitro Drug Metabolism Studies Using Human Liver Microsomes
    https://doi.org/10.5772/intechopen.108246
49. Anchi, P.; Chilvery, S.; Tekalkar, S.; Gajula, S. N. R.; Sonti, R..; Godugu, C. Journal of Drug Delivery Science and Technology, 2022, 75, 103638.
    Nimbolide loaded sustained release microparticles as single-dose formulations for effective management of arthritis
    https://doi.org/10.1016/j.jddst.2022.103638
50. Moi, S.; Shekh, S.; Reddy, K. K. A.; Dhurjad, P.; Sonti, R.; Gowd K. H. Photochemistry and Photobiology, 2022.
    Peptide Cysteine Thiols Act as Photostabilizer of Avobenzone through Stabilizing the Transition State of Keto‐Enol Tautomerization
    https://doi.org/10.1111/php.13691
51. Gajula, S. N. R.; Navin, N. T.; Talari, S.; Shende, C.; Sonti, R.. Bioanalysis, 2022, 12, 881.
    Green bioanalysis: an innovative and eco-friendly approach for analyzing drugs in biological matrices
    https://doi.org/10.4155/bio-2022-0095
52. Dandekar, M. P.; Palepu, M. S. K.; Satti, S.; Jaiswal, Y.; Singh, A. A.; Dash, S. P.; Gajula, S. N. R.; Sonti, R. ACS Chemical Neuroscience, 2022, 13, 1948.
    Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety-and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats
    https://doi.org/10.1021/acschemneuro.2c00143
53. Santosh, K. S.; Sarvan, M.; Siva, N. R. G.; Mohammad, N. A.; Grace, K.; Srinivas, N.; Sonti, R.; Arunava, D.; Sidharth, C.; Venkata, M. Y. Bioorganic & Medicinal Chemistry, 2022, 64, 116777.
    Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy
    https://doi.org/10.1016/j.bmc.2022.116777
54. Grzesiek, S.; Paladini, J.; Habazettl, J.; Sonti, R. Magnetic Resonance, 2022, 3, 1.
    Imatinib disassembles the regulatory core of Abelson kinase by binding to its ATP site and not by binding to its myristoyl pocket
    https://doi.org/10.5194/mr-3-91-2022
55. Gaurav, P.; Shaik, M. G.; Swayamsiddha, K.; Sai, M. C.; Dannarm, S. R.; Jitendra, G.; Sonti, R.; Srinivas. N. Chemistry - An Asian Journal, 2022, 17, 8.
    SmI2-mediated C-alkylation of Ketones with Alcohols in Microwave conditions: A Novel Route to Alkylated Ketones
    https://doi.org/10.1002/asia.202200041
56. Makhal, P. N.; Dannarm, S. R.; Shaikh, A. S.; Sonti, R.; Kaki, V. R. ChemistrySelect, 2022, 7, 14.
    TBHP‐Mediated Selenocyclization of N‐Allylbenzamides/Benzthioamides via In‐Situ Generation of “PhSeOH” Species
    https://doi.org/10.1002/slct.202200933
57. Gaurav, P.; Shaik, M. G.; Swanand, V. J.; Preeti, R.; Swayamsiddha, K.; Mahesh, P. S.; Dannarm, S. R.; Sonti, R.; Srinivas. N. ChemistrySelect, 2022, 7, 14.
    Cu(I)-Catalyzed Microwave-Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3-b ]quinazolin-8-ones and Their Photophysical Study
    https://doi.org/10.1002/slct.202200500
58. Dhurjad, P.; Dhavaliker, C.; Gupta, K.; Sonti, R. Drug Metab Dispos., 2022, 50, 224.
    Exploring Drug Metabolism by the Gut Microbiota: Modes of Metabolism and Experimental Approaches
    https://doi.org/10.1124/dmd.121.000669
59. Bora, D.; Reddy, S.; Stephy Elsa, J.; Sravani, S.; Sonti, R.; Shankaraiah, N. Asian J. Org. Chem., 2021, 10, 3384.
    Regioselective ortho-sulphonamidation of β-carbolines: Exploration of Intrinsic directing property of β-carbolines and their photophysical studies
    https://doi.org/10.1002/ajoc.202100602
60. Gangireddy, N. R.; Laltanpuii.; Sonti, R. Bioanalysis, 2021, 22, 1697.
    Review on in vivo profiling of drug metabolites with LC-MS/MS in the past decade
    https://doi.org/10.4155/bio-2021-0144
61. Rao, G. S. N.; Megha, S. P.; Samanthula, G.; Sonti, R. Bioanlaysis, 2021, 13, 17.
    Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies in drug discovery and development
    https://doi.org/10.4155/bio-2021-0132
62. Rao, G. S. N.; Nimisha, N.; Sonti, R. Drug Metab Rev., 2021, 53, 49.
    Drug Metabolic Stability in Early Drug Discovery to Develop Potential Lead Compounds
    https://doi.org/10.1080/03602532.2021.1970178
63. Cherix, A.; Sonti, R.; Lanz, B.; Lei, H ​ Metabolites, 2021, 11, 50.
    In vivo metabolism of [1,6- 13c2] glucose reveals distinct neuroenergetic functionality between mouse hippocampus and hypothalamus
    https://doi.org/10.3390/metabo11010050
64. Rao, G. S. N.; Reddy, G.N.; Reddy, D. S.; Sonti, R. Bioanlaysis, 2020,12, 1647.
    Pharmacokinetic drug-drug interactions: an insight into recent US FDA-approved drugs for prostate cancer
    https://doi.org/10.4155/bio-2020-0242
65. Ines, H. H.; Lamontanara, A. J.; Hantschel, O.; Grzesiek, S. J. Am. Chem. Soc., 2018, 140, 1863.
    ATP site ligands determine the assembly state of the Abelson kinase regulatory core via the activation loop conformation. Sonti, R.
    https://doi.org/10.1021/jacs.7b12430
66. Yarava, J. R.; Sonti, R.; Kantharaju, K.; Raghothama, S.; Ramanathan, K. V. Chem Commun., 2017, 53, 1317.
    Solid-state NMR at natural isotopic abundance for the determination of conformational polymorphism - the case of designed β-turn peptides containing di-prolines Amino Acids
    https://doi.org/10.1039/c6cc08676d
67. Chandrappa, S.; Madhusudana, R. M. B.; Sonti, R.; Basuroy, K.; Raghothama. S.; Balaram, P. Amino Acids, 2015, 47, 291.
    Directing peptide conformation with centrally positioned pre-organized dipeptide segments: studies of a 12-residue helix and β-hairpin
    https://doi.org/10.1007/s00726-014-1858-0
68. Sonti, R.; Rao, K.N.; Chidanand, S.; Gowd, K. H.; Raghothama, S.; Balaram, P. Chem. Eur. J., 2014, 20, 5075.
    Conformational analysis of a novel 20 membered cyclic peptide disulfide from Conus virgo with a WPW segment: Evidence for an aromatic-proline sandwich
    https://doi.org/10.1002/chem.201303687
69. Sonti, R.; Dinesh, B.; Basuroy, K.; Ragothama, S.; Shamala, N.; Balaram, P. Org. Lett., 2014, 16, 1656.
    C12 helices in long hybrid (αγ)n peptides composed entirely of unconstrained residues with proteinogenic sidechains
    https://doi.org/10.1002/chem.201303687
70. Sonti, R.; Gowd, K. H.; Rao, K. N.; Raghothama, S.; Rodriguez, A.; Perez, J. J.; Balaram, P. Chem. Eur. J., 2013, 45, 15175.
    Conformational diversity in contryphans from conus venom. Cis/trans isomerisation and aromatic/proline interactions in the 23 membered ring of a 7-residue peptide disulfide loop
    https://doi.org/10.1002/chem.201301722
71. Sonti, R.; Gopi, H. N.; Muddegowda, U.; Raghothama, S.; Balaram, P. Chem. Eur. J. 2013., 19 5955.
    A designed three stranded β-sheet in a α/β hybrid peptide
    https://doi.org/10.1002/chem.201204327
72. Sonti, R.; Rai. R.; Raghothama, S.; Balaram, P. J Phys Chem B., 2012, 116, 14207.
    NMR analysis of cross strand aromatic interactions in an 8 residue hairpin and a 14 residue three stranded β sheet peptide
    https://doi.org/10.1021/jp3034769
73. Chandrappa, S.; Aravinda, S.; Raghothama, S.; Sonti, R.; Rai, R.; Harini, V. V.; Shamala, N.; Balaram, P. Org. Biomol. Chem., 2012, 10, 2815.
    Helix and hairpin nucleation in short peptides using centrally positioned conformationally constrained dipeptide segments
    https://doi.org/10.1039/c2ob06817f
74. Ganesh, N. V.; Ragothama, S.; Sonti, R.; Jayaraman, N. J. Org. Chem., 2010, 75, 215.
    Ring expansion of oxyglycals. Synthesis and conformational analysis of septanoside-containing trisaccharides
    https://doi.org/10.1021/jo901945e

PATENTS

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INVITED TALKS

1. Gave a keynote lecture on “Importance of NMR for characterizing degradation impurities” for a special one-day symposium on the Current trends in NMR spectroscopy held at CSIR–IICTon 22 July 2024.
2. Gave a talk on “peptides and impurity identification by NMR” at Revealing Molecular Mysteries through NMR Spectroscopy organized in partnership with CSIR-IICT Hyderabad and Bruker BioSpin on 20 June 2024.
3. Gave a talk on “Importance of NMR for characterizing degradation impurities” for Mestrelab Research on 9 Feb 2024 in Hyderabad.
4. Gave a talk on “Study on the hydrolytic degradation behavior of bictegravir by LC-PDA-Q/TOF-MS/MS, NMR and in silico toxicity assessment’ in CBMR Lucknow on 4 Feb 2024.
5. Gave a talk on “Conformational analysis of novel conopeptides and recent insights of Abelson tyrosine kinase drug binding mechanism by NMR” in IISER Berhampur on 26 Feb 2023.
6. Gave a webinar on Advanced tools to understand in vitro science and translate it close to in vivo
7. NMR spectroscopy: An analytical technique for chemists and biologists, SRM University, Sikkim, 7 June 2021.
8. Conformational analysis of cyclic peptides by NMR spectroscopy, Seethalakshmi Ramaswamy College, 27 February 2021.
9. NMR spectroscopy for Genotoxic impurity profiling, JSS college of Pharmacy, Ooty, 10-12 November 2020.
10. NMR spectroscopy, Bangalore University, 19-20 August 2020.
11. Basics to Advanced Topics in One Dimensional NMR Spectroscopy, REVA university, Bangalore, 23 May 2020.
12. Gave a talk on “Conformational analysis of peptide toxins and protein-drug interactions in solution by NMR spectroscopy” in December 2019 at NIPER Ahmedabad.
13. Gave a talk on “NMR analysis of peptides and protein drug interactions” in March 2018 at CIBM, EPFL Lausanne
14. Gave a talk on “NMR analysis of synthetic and natural peptides” in July 2013 at Biozentrum, Basel
15. Gave a talk on “Conformational diversity of contryphans by solution NMR” in NMRS 2012, Bangalore

SPONSORED PROJECTS

Structure elucidation of related 2- unknown impurities, Granules India Limited, Rs 3,87,248.

Feasibility studies of peptide for Orbicular pharmaceuticals Ltd, Rs 1,51,984.

QNMR for Orbicular pharmaceuticals Ltd, Rs 49,118.

LABORATORY FACILITIES DEVELOPED

1. NMR experiments for the structure elucidation of pharmaceutical compounds and bioactive peptides.
2. Structural elucidation of alkaloids and terpenoids by UV, IR, Mass and NMR techniques

ADDITIONAL RESPONSIBILITIES

1. NMR facility in charge
2. Chair, International relations, Consulting, Alumni affairs Committee
3. Co-Chair, National Centre for Research and Development in Bulk Drug (NCRDBD)
4. Chair, International relations, Consulting, Alumni affairs Committee
5. Chief Warden, Boy's Hostel
6. Member, Industry interaction and international collaboration cell
7. Member, Board of Studies and Research
8. Member, Stores and Purchase (Capital)

ANY OTHER INFORMATION