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Faculty Profile : Dr. Srinivas Nanduri

Name: Dr. Srinivas Nanduri


Professor
nanduri.niperhyd@gov.in
+91 40 23074750 Extn- 2007
Google Scholar Citations


ADDRESS, ROOM NO,

Department of Chemical Sciences
Room. No. 15 & 16, NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA



QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

  1. PhD (Chemistry): Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, A.P. India (1991)
  2. M.Sc (Chemistry): Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, A.P. India (1988)
  3. B.Sc (Chemistry): Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, A.P. India (1986)



EXPERIENCE
  1. Professor, Department of Chemical Sciences at NIPER Hyderabad (Dec 2019 – Present)
  2. Dean, NIPER Hyderabad (March, 2020 to September, 2021)
  3. Associate Professor, Department of Chemistry at Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, A.P. India (Aug 2019- Dec 2019)
  4. Associate Professor, Department of Process Chemistry at NIPER Hyderabad (Sep 2013- July 2019)
  5. Director, Medicinal Chemistry department at Albany Molecular Research (India), Hyderabad (June 2012- June 2013)
  6. Research Director, Aurigene Discovery Technologies Ltd., Bangalore (Dec 2008- May 2012)
  7. Chief Scientific Manager, Biocon BMS Research Centre, Bangalore (March 2008- Nov 2008)
  8. Senior Director, Dr. Reddy’s Laboratories Ltd., Hyderabad, INDIA (Sep 1995- Feb 2008)
  9. Lecturer, Sri Sathya Sai Institute of Higher Learning, Prasanthinilayam, A.P. India (Jan 1992 – Aug 1995)


COURSES HANDLING(PHD/M.PHARM)

  1. PT-560 : Synthetic Aspects of Process Chemistry
  2. PT-630 : Synthetic Bulk Drug Technology
  3. LG-510 : General Laboratory Experience
  4. MC-650: Stereochemistry and Drug Action
  5. PT-710: Technologies for Green Chemistry
  6. NP-720: Natural Product-Based Drugs and Lead Molecules



PHD STUDENTS/MASTERS STUDENTS

Guided more than 50 M.S. (Pharm) / M. Tech (Pharm) students.
PhD: 5 (Guide) completed
10 ongoing



AWARDS / HONOURS

-



RESEARCH AREAS/INTEREST

  • Drug Discovery & Development in the areas of
    •        a. Anti-microbial
           b. Anti-cancer
           c. Neurodegenerative disorders
  • Process Optimization and Green Chemistry.
  • Natural products, Isolation and Characterization, total synthesis and semi-synthesis.



    • SPONSORED PROJECTS
    S.No Title of the Project Funding Organization Role Amount (In INR) Status
    1 Design, synthesis, and development of scalable route towards novel compounds based on the hybrid structure of Hymenialdisins and Paullones and a novel scaffold derived from Variolins Ministry of Earth Sciences Principal Investigator (PI) 45 Lakhs (2016-2019) Completed
    2 Synthesis and therapeutic evaluation of new LpxC inhibitors as potent anti- bacterial agents DST-SERB Principal Investigator (PI) 43 Lakhs (2017-2020) Completed
    3 Repurposing Oxiconazole: Alone and in combination with PUFA's as a broad spectrum antibacterial agents DBT Co-Principal Investigator (Co-PI) 40 Lakhs (2019-2022) In Progress
    4 Design, synthesis and biological evaluation of new GSK3β; inhibitors as promising therapeutic agents for treating Traumatic brain injury and consequent neuronal degenerative diseases ICMR Principal Investigator (PI) 50 Lakhs (2020-2023) In Progress
    5 Development of a scalable route for the manufacture of Prussian Blue insoluble of Pharmaceutical grade, an FDA approved decorporation drug LSRB Co-Principal Investigator (Co-PI) 49 Lakhs (2019-2022) In Progress


    PUBLICATIONS / BOOK CHAPTERS
    1. Kalam, A.; Sahu, N. R.; Tamang, N.; Harsil, J.; Rana, P.; Yaddanapudi, V. M.; Nanduri, S. Efforts Toward the Development of an Efficient Synthetic Process for Levetiracetam: An Anti-Epileptic Drug. ChemistrySelect 2026, 11(34), e74356. https://doi.org/10.1002/slct.74356
    2. Joshi, S. V.; Srikanth, D.; Kalam, A.; Pawar, G.; Bhale, N. A.; Dikundwar, A. G.; Yaddanapudi, V. M.; Nanduri, S. Microwave-Assisted Copper-Mediated One-Pot Sequential Synthesis of Quinolino[3,4-b]quinoxalines. Eur. J. Org. Chem. 2026, e70802. https://doi.org/10.1002/ejoc.70802
    3. Varpe, P.; Dask, T. K.; Srivastava, S.; Nanduri, S. Investigating the Landscape of Personalized Medicine Approvals by the FDA. J. Pharm. Innov. 2026, 21(6), 566. https://doi.org/10.1007/s12247-026-10867-6
    4. Manasa, V.; Jayaprakash, S.; Paoletti, N.; Srikanth, D.; Tamang, N.; Soujanya, D.; Shaik, M. G.; Yaddanapudi, V. M.; Supuran, C. T.; Nanduri, S. Synthesis and Biological Evaluation of Indole-Benzene Sulfonamides as Carbonic Anhydrase II, IX, and XII Inhibitors. ChemMedChem 2026, 21(13), e70374. https://doi.org/10.1002/cmdc.70374
    5. Singampalli, A.; Kumar, P.; Bandela, R.; Devi, A.; Nanduri, S.; Yaddanapudi, V. M. Expanding the Tetrazole Space: Medicinal Chemistry, Biological Diversity and Structure-Activity Relationships. Future Med. Chem. 2026, 1–19. https://doi.org/10.1080/17568919.2026.2688846
    6. Bellapukonda, S. M.; KT, M. A.; Mishra, S.; Kodi, R.; Ghosh, S.; Korra, L. N.; Nanduri, S.; Yaddanapudi, V. M. A Comprehensive Review of Indole Hybrids as Anti-Bacterial and Anti-Fungal Agents: Synthetic Protocols and SAR Studies. Future Med. Chem. 2026, 18(9), 1101–1131. https://doi.org/10.1080/17568919.2026.2642582
    7. Kumari, D.; Ghouse, S. M.; Sinha, K.; Kalam, A.; Singh, K.; Nanduri, S. Coumarin Derivatives as New Chemotype Targeting Leishmanial Sterol Biosynthesis Pathway Proteins: An Integrated In Vitro, Mechanistic, and In Silico Evaluation. World J. Microbiol. Biotechnol. 2026, 42(5), 202. https://doi.org/10.1007/s11274-026-04916-y
    8. Joshi, S. V.; Patil, S.; Srikanth, D.; Shaikh, A. S.; Kalam, A.; Tamang, N.; Suradkar, R. V.; Dikundwar, A. G.; Yaddanapudi, V. M.; Nanduri, S. Molecular Iodine Enabled Cascade Oxidation and Annulation for the Construction of Polycyclic 5-Aroyl-5,6-Dihydropyrazolo[1,5-c]Quinazolines. Asian J. Org. Chem. 2026, 15(4), e70389. https://doi.org/10.1002/ajoc.70389
    9. Bellapukonda, S. M.; Parida, K. K.; Bandela, R.; Kumar, P.; Lahiri, M.; Kalia, N. P.; Nanduri, S.; Yaddanapudi, V. M. Exploration of 1,3-Di Substituted Pyrazole Conjugates as DNA Gyrase Inhibitors to Combat Staphylococcus aureus and Mycobacterium tuberculosis. Bioorg. Chem. 2026, 15(174), 109716. https://doi.org/10.1016/j.bioorg.2026.109716
    10. Kumar, P.; Singampalli, A.; Bandela, R.; Bellapukonda, S. M.; Kodi, R.; Ghosh, S.; Korra, L. N.; Dalal, A.; Devi, A.; Kalia, N. P.; Nanduri, S.; Yaddanapudi, V. M. Structure-Activity Relationship-Driven Lead Optimization of Pyrazole Hydrazide-Hydrazone Analogues as Potent Antimycobacterial Agents: In Vitro and In Silico Studies. Bioorg. Med. Chem. Lett. 2026, 136, 130601. https://doi.org/10.1016/j.bmcl.2026.130601
    11. Manasa, V.; Ghouse, S. M.; Paoletti, N.; Sinha, K.; Danaboina, S.; Tamang, N.; Soujanya, D.; Yaddanapudi, V. M.; Supuran, C. T.; Nanduri, S. Exploring Coumarin-Triazole Derivatives as Selective Inhibitors of Carbonic Anhydrase IX and XII. ChemMedChem 2026, 21(4), e202500959. https://doi.org/10.1002/cmdc.202500959
    12. Rana, P.; Supriya, M. S.; Srikanth, D.; Ammara, A.; Warake, R.; Gandhe, H.; Yaddanapudi, V. M.; Supuran, C. T.; Nanduri, S. Exploration of Novel 4-Substituted Coumarin Derivatives as Selective Human Carbonic Anhydrase IX and XII Inhibitors: Synthesis, Biological Evaluation, and In Silico Studies. Chem. Biodivers. 2025, 22(12), e01800. https://doi.org/10.1002/cbdv.202501800
    13. Kumar, P.; Singampalli, A.; Bandela, R.; Bellapukonda, S. M.; Korra, L. N.; Kodi, R.; Ghosh, S.; Dalal, A.; Agnivesh, P. K.; Devi, A.; Nanduri, S.; Kalia, N. P.; Paoletti, N.; Bonardi, A.; Gratteri, P.; Supuran, C. T.; Yaddanapudi, V. M. Exploration of New Pyrazole-Hydrazone-Benzenesulfonamide Conjugates as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation. ChemMedChem 2025, 20(23), e202500633. https://doi.org/10.1002/cmdc.202500633
    14. Maddipatla, S.; Bakchi, B.; Agnivesh, P. K.; Meshram, S.; Mazumdar, C. K.; Ghouse, S. M.; Singampalli, A.; Rani, B.; Kumar, P.; Nanduri, S.; Kalia, N. P.; Yaddanapudi, V. M. Identification of Novel MmpL3 Inhibitors Using In Silico Methods: Virtual Screening, Rational Design, and Biological Evaluation. J. Mol. Struct. 2025, 1354, 144902. https://doi.org/10.1016/j.molstruc.2025.144902
    15. Yerram, S.; Nizam, V. M.; Srivastava, S.; Nanduri, S. Nitrosamine Contamination in Pharmaceuticals: A Retrospective Regulatory Analysis of USFDA Recalls and Risk Mitigation Strategies (2018–2025). Ther. Innov. Regul. Sci. 2025, 60(2), 519–533. https://doi.org/10.1007/s43441-025-00891-y
    16. Kalam, A.; Tiwari, M.; Pawar, G.; Srikanth, D.; Joshi, S. V.; Bhale, N. A.; Dikundwar, A. G.; Yeddanapudi, M. V.; Nanduri, S. Sodium Dithionite-Mediated One-Pot, Tandem Reductive Cyclization of 2-(2-Nitrophenyl)quinazolin-4(3H)-one with Diverse Aldehydes and Glyoxals. Synthesis 2025, 57(20), 2983–2996. https://doi.org/10.1055/a-2655-458
    17. Bellapukonda, S. M.; Singothu, S.; Singampalli, A.; Bandela, R.; Kumar, P.; Yaddanapudi, V. M.; Bhandari, V.; Nanduri, S.; Enneiymy, M.; AlAjm, M. F.; Oubella, A. Exploring Spirocyclic Isoquinoline-Piperidine Compounds in Tuberculosis Therapy: ADMET Profiling, Docking, DFT, MD Simulations, and MMGBSA Analysis. Comput. Biol. Chem. 2025, 118, 108447. https://doi.org/10.1016/j.compbiolchem.2025.108447
    18. Bandela, R.; Tupare, R. R.; Saxena, D.; Maitra, R.; Singampalli, A.; Bellapukonda, S. M.; Kumar, P.; Bakchi, B.; Polshettiwar, S.; Nanduri, S.; Chopra, S.; Yaddanapudi, V. M. Synthesis and Antibacterial Evaluation of 5-(3-Nitrophenyl)-N'-Arylisoxazole-3-Carbohydrazide Derivatives against Carbapenem-Resistant Acinetobacter baumannii. Eur. J. Med. Chem. 2025, 300, 118154. https://doi.org/10.1016/j.ejmech.2025.118154
    19. Kumar, P.; Singampalli, A.; Bandela, R.; Bellapukonda, S. M.; Maddipatla, S.; Dalal, A.; Devi, A.; Nanduri, S.; Kalia, N. P.; Paoletti, N.; Supuran, C. T.; Madhavi, Y. V. Structural Insights into Arylidenehydrazinyl Benzenesulfonamides as Potent Mycobacterial Carbonic Anhydrase Inhibitors. Future Med. Chem. 2025, 17(17), 2131–2144. https://doi.org/10.1080/17568919.2025.2552642
    20. Joshi, S. V.; Soujanya, D.; Supriya, M. S.; Yaddanapudi, V. M.; Nanduri, S. Glycogen Synthase Kinase 3β (GSK-3β) Inhibitors—A Patent Update (2019–2024). Expert Opin. Ther. Pat. 2025, 35(9), 933–945. https://doi.org/10.1080/13543776.2025.2536003
    21. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Bandela, R.; Bakchi, B.; Bhale, N. A.; Dikundwar, A. G.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Madhavi, Y. V. Exploration of Pyridine-4-Hydrazide Derivatives as Promising Antitubercular Agents: Synthesis, Biological Evaluation, and In Silico Studies. ChemistrySelect 2025, 10(36), e01301. https://doi.org/10.1002/slct.202501301
    22. Singampalli, A.; Bandela, R.; Bakchi, B.; Maddipatla, S.; Kumar, P.; Bellapukonda, S. M.; Agnivesh, P. K.; Parida, K. K.; Giovannuzzi, S.; Biernacki, K.; Bonardi, A.; Gratteri, P.; Bhalerao, H. A.; Sonti, R.; Nanduri, S.; Supuran, C. T.; Kalia, N. P.; Yaddanapudi, M. V. Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and In Silico Studies. J. Med. Chem. 2025, 68(17), 18370–18388. https://doi.org/10.1021/acs.jmedchem.5c01026
    23. Ommi, O.; Bhalerao, H. A.; Malik, P.; Ali, J.; Saxena, D.; Nanduri, S.; Sonti, R.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Synthesis of 1,3-Diaryl Substituted Pyrazole-Based Imidazo[1,2-a]pyridine Carboxamides and Evaluation of Their Antitubercular Activity. Bioorg. Med. Chem. 2025, 129, 118341. https://doi.org/10.1016/j.bmc.2025.118341
    24. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Rani, B.; Bellapukonda, S. M.; Devi, A.; Bhale, N. A.; Dikundwar, A. G.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Madhavi, Y. V. Exploration of New Dihydroindazole Derivatives as Promising Anti-TB Agents: Design, Synthesis, In Silico, and Biological Evaluation. Arch. Pharm. 2025, 358(8), e70074. https://doi.org/10.1002/ardp.70074
    25. Rokkam, S. K.; Chowdhury, S.; Inabathina, Y.; Sripada, L.; Nanduri, S.; Karanam, B.; Golakoti, N. R. Novel 3,19-(N-Phenyl-3-(4-Fluorophenyl)-Pyrazole) Acetal of Andrographolide Promotes Cell Cycle Arrest and Apoptosis in MDA-MB-231 Breast Cancer Cells. Pharmaceuticals 2025, 18(7), 1026. https://doi.org/10.3390/ph18071026
    26. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Bandela, R.; Bellapukonda, S. M.; Rajyalakshmi, S. I.; Bhale, N. A.; Dikundwar, A. G.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Exploration of Pyrazole-Based Pyridine-4-Carbohydrazide Derivatives as Drug-Resistant Mtb Agents: Design, Synthesis, Biological Evaluation, and In-Silico Studies. Future Med. Chem. 2025, 17(12), 1391–1405. https://doi.org/10.1080/17568919.2025.2525069
    27. Rana, P.; Supriya, M. S.; Ahmad, M. N.; Imran, M.; Malik, P.; Mahajan, R.; Asthana, A.; Madhavi, Y.; Dasgupta, A.; Chopra, S.; Nanduri, S. Synthesis, Biological Evaluation, and Structure–Activity Relationships of Pyrrole Coumarin Conjugates Against Mycobacterium tuberculosis. ChemistrySelect 2025, 10(28), e1069. https://doi.org/10.1002/slct.202501069
    28. Singampalli, A.; Bandela, R.; Bakchi, B.; Giovannuzzi, S.; Biernacki, K.; Agnivesh, P. K.; Nanduri, S.; Kalia, N. P.; Supuran, C. T.; Yaddanapudi, V. M. Exploration of 3-Substituted Benzofuran-Tethered Sulfamoyl Triazoles as Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation. ChemMedChem 2025, 2500080. https://doi.org/10.1002/cmdc.202500080
    29. Radapaka, K.; Mourya, A.; Singh, H.; Loharkar, S.; Bansode, A.; Guru, S. K.; Doijad, N.; Nanduri, S.; Madan, J. Glucosamine Sulphate Endorsed Ibuprofen Nanocrystals Burdened Polymeric Gel Demonstrated Multidimensional Anti-Inflammatory and Cartilage Protective Potential in Experimental Knee Osteoarthritis: In Vitro and In Vivo Studies. Int. J. Pharm. 2025, 677, 125660. https://doi.org/10.1016/j.ijpharm.2025.125660
    30. Akki, A. J.; Nanduri, S.; Patil, S. V.; Das, K. K.; Parvatikar, P. Exploring the microRNA-Mitochondrial Nexus in Hepatocellular Carcinoma. Mitochondrion 2025, 102045. https://doi.org/10.1016/j.mito.2025.102045
    31. Singampalli, A.; Bandela, R.; Kumar, P.; Bakchi, B.; Maddipatla, S.; Bellapukonda, S. M.; Nanduri, S.; Shukla, R.; Mishra, K.; Madhavi, Y. V. Exploration of Benzofuran/Indole-Chalcone Conjugated 1,2,3-Triazole Hybrids as Candida glabrata Agents: Design, Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Analysis. Chem. Biodivers. 2025, 22(8), e202500345. https://doi.org/10.1002/cbdv.202500345
    32. Kumar, P.; Singampalli, A.; Bandela, R.; Srimounika, B.; Rajyalakshmi, S. I.; Devi, A.; Nanduri, S.; Madhavi, Y. V. Spirocyclic Compounds: Potential Drug Leads in the Fight Against Mycobacterium tuberculosis. Future Med. Chem. 2025, 17(7), 819–837. https://doi.org/10.1080/17568919.2025.2479413
    33. Srikanth, G.; Beda, D. P.; Dwivedi, A. R.; Duddukuri, N. K.; Nanduri, S.; Patel, J. Promising New Anti-TIGIT Agents: Stealthy Allies in Cancer Immunotherapy. Clin. Transl. Sci. 2025, 18(4), e70212. https://doi.org/10.1111/cts.70212
    34. Bandela, R.; Sahoo, S. K.; Mukhopadhyay, A.; Imran, M.; Singampalli, A.; Maddipatla, S.; Bellapukonda, S. M.; Panchal, D.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Design, Synthesis and Biological Evaluation of Ethyl 5-(1-Benzyl-1H-Indol-5-yl) Isoxazole-3-Carboxylates as Antimycobacterial Agents. ChemMedChem 2024, 20(7), e202400902. https://doi.org/10.1002/cmdc.202400902
    35. Maddipatla, S.; Agnivesh, P. K.; Bakchi, B.; Nanduri, S.; Kalia, N. P.; Yaddanapudi, V. M. New Pyrazole-Based Derivatives Targeting MmpL3 Transporter in Mycobacterium tuberculosis: Design, Synthesis, Biological Evaluation and Molecular Docking Studies. Mol. Divers. 2025, 29(6), 6437–6458. https://doi.org/10.1007/s11030-025-11152-3
    36. Bellapukonda, S. M.; Bandela, R.; Singampalli, A.; Srikanth, D.; Kumar, P.; Nanduri, S.; Yaddanapudi, V. M. A Systematic Review on the Anti-Microbial Activities and Structure-Activity Relationship (SAR) of Quinoxaline Derivatives. Eur. J. Med. Chem. 2025, 289, 117472. https://doi.org/10.1016/j.ejmech.2025.117472
    37. Bakchi, B.; Devabattula, G.; Maddipatla, S.; Singampalli, A.; Porna, D. K.; Nanduri, S.; Sharma, A.; Godugu, C.; Yaddanapudi, V. M. New Indole-Based Phenylthiazolyl-2,4-Dihydropyrazolones as Tubulin Polymerization Inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and In Silico Studies. ChemMedChem 2024, 20(5), e202400817. https://doi.org/10.1002/cmdc.202400817
    38. Bandela, R.; Singampalli, A.; Maddipatla, S.; Kumar, P.; Bellapukonda, S. M.; Ramavath, R.; Mahajan, L. S.; Nanduri, S.; Vemula, D.; Dalal, A.; Bhandari, V.; Gratteri, P.; Paoletti, N.; Bonardi, A.; Supuran, C. T.; Yaddanapudi, V. M. Design and Synthesis of Isoxazole-Functionalized Benzene Sulphonamides as Novel Inhibitors of Mycobacterium tuberculosis β-Carbonic Anhydrases. RSC Med. Chem. 2025, 16(12), 6368–6379. https://doi.org/10.1039/d5md00744e
    39. Kumar, P.; Singampalli, A.; Bandela, R.; Bellapukonda, S. M.; Nanduri, S.; Yaddanapudi, V. M. Therapeutic Potential of Spiro Compounds against Staphylococcus aureus: A Comprehensive Review. RSC Med. Chem. 2025, 16(12), 5925–5952. https://doi.org/10.1039/d5md00497g
    40. Singampalli, A.; Kumar, P.; Bandela, R.; Bellapukonda, S. M.; Nanduri, S.; Yaddanapudi, V. M. Indazole—An Emerging Privileged Scaffold: Synthesis and Its Biological Significance. RSC Med. Chem. 2025, 16(11), 5196–5221. https://doi.org/10.1039/d5md00336a
    41. Srikanth, D.; Shejul, G. D.; Joshi, S. V.; Kalam, A.; Jahnavi, A. S.; Dikundwar, A. G.; Chopra, S.; Yaddanapudi, M. V.; Nanduri, S. Transition Metal-Free One-Pot Tandem Chemoselective Reduction and Cyclization of 3/5-(2-Nitrophenyl)-1H-Pyrazoles Using Sodium Dithionite. Org. Biomol. Chem. 2025, 23(24), 5812–5820. https://doi.org/10.1039/d5ob00610d
    42. Tamang, N.; Pati, D. R.; Sripada, L.; Nanduri, S.; Golakoti, N. R. Synthesis, Structural, Spectroscopic, and Anticancer Studies of 3,19-Furfurylidene-12(S)-thiophenyl-14-deoxy-andrographolide Against 58 Different Cell Lines of Nine Different Cancer Types. ChemistrySelect 2025, 10(3), e202404092. https://doi.org/10.1002/slct.202404092
    43. Maddipatla, S.; Bakchi, B.; Shinde, M. A.; Bonardi, A.; Raman, P. K.; Bhalerao, H. A.; Singampalli, A.; Nanduri, S.; Godugu, C.; Sonti, R.; Supuran, C. T.; Yaddanapudi, V. M. New 7-Hydroxycoumarin Acetamide Derivatives as Human Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies. Arch. Pharm. 2025, 358(1), e2400482. https://doi.org/10.1002/ardp.202400482
    44. Ommi, O.; Dhopat, P. S.; Sau, S.; Estharla, M. R.; Nanduri, S.; Kalia, N. P.; Yaddanapudi, V. M. Design, Synthesis, and Biological Evaluation of Pyrazole-Ciprofloxacin Hybrids as Antibacterial and Antibiofilm Agents against Staphylococcus aureus. RSC Med. Chem. 2025, 16(1), 420–428. https://doi.org/10.1039/d4md00623b
    45. Srikanth, D.; Shanthi, K.; Paoletti, N.; Joshi, S. V.; Shaik, M. G.; Rana, P.; Vadakattu, M.; Yaddanapudi, V. M.; Supuran, C. T.; Nanduri, S. Exploration of 1,3,5-Trisubstituted Pyrazoline Derivatives as Human Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation and In Silico Studies. Int. J. Biol. Macromol. 2025, 280, 135890. https://doi.org/10.1016/j.ijbiomac.2024.135890
    46. Bakchi, B.; Maddipatla, S.; Gottemukkala, S.; Raut, S.; Ahmad, M. N.; Imran, M.; Saxena, D.; Maitra, R.; Agnivesh, P. K.; Kalia, N. P.; Nanduri, S.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Benzyl/Phenyl-1,2,3-Triazole Tethered 3-Acetyl Coumarins as Potential Drug-Resistant Antitubercular Agents: Synthesis, Biology, and In Silico Investigations as Mtb DNA Gyrase Inhibitors. ChemistrySelect 2024, 9(39), e202402316. https://doi.org/10.1002/slct.202402316
    47. Bakchi, B.; Devabattula, G.; Maddipatla, S.; Singampalli, A.; Porna, D. K.; Nanduri, D. S.; Sharma, A.; Godugu, D. C.; Yaddanapudi, D. V. M. New Indole-Based Phenylthiazolyl-2,4-Dihydropyrazolones as Tubulin Polymerization Inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and In Silico Studies. ChemMedChem 2024, 20(5), e202400817. https://doi.org/10.1002/cmdc.202400817
    48. Malasala, S.; Polomani, A.; Gour, J.; Nanduri, S. Candida antarctica Lipase B Catalyzed Condensation Reactions: Water Mediated Chemo-Enzymatic Synthesis of Different Heterocycles. Tetrahedron Lett. 2024, 153, 155371. https://doi.org/10.1016/j.tetlet.2024.155371
    49. Kalam, A.; Ghouse, S. M.; Joshi, S. V.; Tamang, N.; Sahu, N. R.; Yaddanapudi, M. V.; Nanduri, S. Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug. Org. Process Res. Dev. 2024, 28(9), 3509–3523. https://doi.org/10.1021/acs.oprd.4c00233
    50. Rana, P.; Supriya, M. S.; Kalam, A.; Eedulakanti, C.; Kaul, G.; Akhir, A.; Sindhuja, R. H.; Roy, A.; Agnivesh, P. K.; Saxena, D.; Ahmad, M. N.; Madhavi, Y.; Dasgupta, A.; Kalia, N. P.; Nagesh, N.; Chopra, S.; Nanduri, S. Synthesis and Antibacterial Evaluation of New Naphthalimide-Coumarin Hybrids against Multidrug-Resistant S. aureus and M. tuberculosis. J. Mol. Struct. 2024, 1307, 137957. https://doi.org/10.1016/j.molstruc.2024.137957
    51. Maddipatla, S.; Bakchi, B.; Gadhave, R. R.; Ammara, A.; Sau, S.; Rani, B.; Nanduri, S.; Kalia, N. P.; Supuran, C. T.; Yaddanapudi, V. M. Exploring Rhodanine Linked Enamine-Carbohydrazide Derivatives as Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies. Arch. Pharm. 2024, 357(7), 2400064. https://doi.org/10.1002/ardp.202400064
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    114. Kandanur, S. G. S.; Kundu, S.; Cadena, C.; Juan, H. S.; Bajaj, A.; Guzman, J. D.; Nanduri, S.; Golakoti, N. R. Design, Synthesis, and Biological Evaluation of New 12-Substituted-14-Deoxy-Andrographolide Derivatives as Apoptosis Inducers. Chem. Pap. 2019, 73(7), 1669. https://doi.org/10.1007/s11696-019-00718-9
    115. Gour, J.; Gatadi, S.; Malasala, S.; Yaddanpudi, M. V.; Nanduri, S. A Microwave-Assisted SmI2-Catalyzed Direct N-Alkylation of Anilines with Alcohols. J. Org. Chem. 2019, 84(11), 7488–7494. https://doi.org/10.1021/acs.joc.9b00717
    116. Kandanur, S. G.; Tamang, N.; Golakoti, N. R.; Nanduri, S. Andrographolide: A Natural Product Template for the Generation of Structurally and Biologically Diverse Diterpenes. Eur. J. Med. Chem. 2019, 176, 513–533. https://doi.org/10.1016/j.ejmech.2019.05.022
    117. Gatadi, S.; Lakshmi, T. V.; Nanduri, S. 4(3H)-Quinazolinone Derivatives: Promising Antibacterial Drug Leads. Eur. J. Med. Chem. 2019, 170, 157. https://doi.org/10.1016/j.ejmech.2019.03.018
    118. Das, S.; Garg, T.; Nanduri, S.; Dasgupta, A.; Chopra, S. Targeting DNA Gyrase to Combat Mycobacterium tuberculosis: An Update. Curr. Top. Med. Chem. 2019, 19(8), 579–593. https://doi.org/10.2174/1568026619666190304130218
    119. Gatadi, S.; Gour, J.; Shukla, M.; Kaul, S. Das.; G.; Dasgupta, A.; Madhavi, Y.; Chopra, S.; Nanduri, S. Synthesis and Evaluation of New 4-Oxoquinazolin-3(4H)-yl Benzoic Acid and Benzamide Derivatives as Potent Antibacterial Agents Effective against Multidrug Resistant. Bioorg. Chem. 2019, 83, 569. https://doi.org/10.1016/j.bioorg.2018.11.007
    120. Gour, J.; Gatadi, S.; Akunuri, R.; Yaddanapudi, M. V.; Nengroo, M. A.; Datta, D.; Chopra, S.; Nanduri, S. Catalyst-Free Facile Synthesis of Polycyclic Indole/Pyrrole Substituted-1,2,3-Triazoles. Org. Biomol. Chem. 2019, 17(35), 8153–8165. https://doi.org/10.1039/c9ob01560d
    121. Holmström, T. H.; Moilanen, A.; TarjaIkonen; Björkman, M. L.; TeroLinnanen; Wohlfahrt, G.; Karlsson, S.; Oksala, R.; Korjamo, T.; Samajdar, S.; Rajagopalan, S.; Chelur, S.; Narayanan, K.; Ramachandra, R. K.; Mani, J.; Nair, R.; Gowda, N.; Anthony, T.; Dhodheri, S.; Mukherjee, S.; Ujjinamatada, R. K.; Nanduri, S.; Ramachandra, M.; Kallio, P. J. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol. Cancer Ther. 2019, 18(1), 28–38. https://doi.org/10.1158/1535-7163.MCT-18-0204
    122. Madhavi, Y.; Gaikwad, N.; Yerra, V. G.; Kalvala, A. K.; Nanduri, S.; Kumar, A. Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health. Curr. Med. Chem. 2019, 26(27), 5207–5229. https://doi.org/10.2174/0929867325666180406120051
    123. Gatadi, S.; Gour, J.; Kaul, G.; Shukla, M.; Dasgupta, A.; Akunuri, R.; Tripathi, R.; Madhavi, Y. V.; Chopra, S.; Nanduri, S. Synthesis of New 3-Phenylquinazolin-4(3H)-One Derivatives as Potent Antibacterial Agents Effective against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA). Bioorg. Chem. 2018, 81, 175–183. https://doi.org/10.1016/j.bioorg.2018.08.012
    124. Gatadi, S.; Gour, J.; Shukla, M.; Kaul, G.; Das, S.; Dasgupta, A.; Malasala, S.; Borra, R. S.; Madhavi, Y. V.; Chopra, S.; Nanduri, S. Synthesis of 1,2,3-Triazole Linked 4(3H)-Quinazolinones as Potent Antibacterial Agents against Multidrug-Resistant Staphylococcus aureus. Eur. J. Med. Chem. 2018, 157. https://doi.org/10.1016/j.ejmech.2018.08.070
    125. Gour, J.; Gatadi, S.; Nagarsenkar, A.; Babu, B. N.; Madhavi, Y. V.; Nanduri, S. Synthesis of Indolo[1,2-b]isoquinoline Derivatives by Lewis Acid-Catalyzed Intramolecular Friedel-Crafts Alkylation Reaction. Eur. J. Org. Chem. 2018, 22, 2817–2821. https://doi.org/10.1002/ejoc.201800162
    126. Kandanur, S. G.; Nanduri, S.; Golakoti, N. R. Synthesis and Biological Evaluation of New C-12 (α/β)-(N-)Sulfamoyl-Phenylamino-14-Deoxy-Andrographolide Derivatives as Potent Anti-Cancer Agents. Bioorg. Med. Chem. Lett. 2017, 27(13), 2854–2862. https://doi.org/10.1016/j.bmcl.2017.04.033
    127. Bathina, S.; Srinivas, N.; Das, U. N. Streptozotocin Produces Oxidative Stress, Inflammation, and Decreases BDNF Concentrations to Induce Apoptosis of RIN5F Cells and Type 2 Diabetes Mellitus in Wistar Rats. Biochem. Biophys. Res. Commun. 2017, 486(2), 406–413. https://doi.org/10.1016/j.bbrc.2017.03.054
    128. Bathina, S.; Nanduri, S.; Das, U. N. BDNF Protects Pancreatic β Cells (RIN5F) against Cytotoxic Action of Alloxan, Streptozotocin, Doxorubicin and Benzo(a)pyrene in Vitro. Metabolism 2016, 65(5), 667–684. https://doi.org/10.1016/j.metabol.2016.01.016
    129. Kandanur, S. G. S.; Golakoti, N. R.; Nanduri, S. Synthesis and in Vitro Cytotoxicity of Novel C-12 Substituted-14-Deoxy-Andrographolide Derivatives as Potent Anti-Cancer Agents. Bioorg. Med. Chem. Lett. 2015, 25(24), 5781–5786. https://doi.org/10.1016/j.bmcl.2015.10.053
    130. Pasha, J.; Kandagatla, B.; Sen, S.; Seerapu, G. P. K.; Bujji, S.; Haldar, D.; Nanduri, S.; Oruganti, S. Amberlyst-15 Catalyzed Povarov Reaction of N-Arylidene-1H-Indazol-6-Amines and Indoles: A Greener Approach to the Synthesis of Exo-1,6,7,7a,12,12a-Hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines as Potential Sirtuin Inhibitors. Tetrahedron Lett. 2015, 56(18), 2289–2292. https://doi.org/10.1016/j.tetlet.2015.03.078
    131. Gummadi, V. R.; Rajagopalan, S.; Chung-YengLooi; Paydar, M.; Renukappa, G. A.; Ainan, B. R.; Krishnamurthy, N. R.; Panigrahi, S. K.; Mahasweta, K.; Raghuramachandran, S.; Rajappa, M.; Ramanathan, A.; Lakshminarasimhan, A.; Ramachandra, M.; Wong, P.; Mustafa, M. R.; Nanduri, S.; Hosahalli, S. Discovery of 7-Azaindole Based Anaplastic Lymphoma Kinase (ALK) Inhibitors: Wild Type & Mutant (L1196M) Active Compounds with Unique Binding Mode. Bioorg. Med. Chem. Lett. 2013, 23(17), 4911–4918. https://doi.org/10.1016/j.bmcl.2013.06.071
    132. Sasmal, P. K.; Talwar, R.; Swetha, J.; Balasubrahmanyam, D.; Venkatesham, B.; Rawoof, K.; Devi, B. N.; Jadhav, V. P.; Khan, S. K.; Mohan, P.; Reddy, D. S.; Nyavanandi, V. K.; Nanduri, S.; Kumar, K. S.; Kannan, M.; Srinivas, P.; Nadipalli, P.; Chaudhury, H.; Sebastian, V. Structure–Activity Relationship Studies of Novel Pyrazole & Imidazole Carbixamides as Cannabinoid-1 (CB1) Antagonists. Bioorg. Med. Chem. Lett. 2011, 21(16), 4913–4918. https://doi.org/10.1016/j.bmcl.2011.06.017
    133. Das, P.; Kumar, C. K.; Kumar, K. N.; Innus, M.; Iqbal, J.; Nanduri, S. Dithiocarbamate&Cuo Promoted One-Pot Synthesis of 2-(N-Substituted)-Aminobenzimidazoles & Related Heterocycles. Tetrahedron Lett. 2008, 49(6), 992–995. https://doi.org/10.1016/j.tetlet.2007.12.022
    134. Basha, S. J.; Naveed, S. A.; Tiwari, N. K.; Shashikumar, D.; Muzeeb, S.; Kumar, T. R.; Kumar, N. V.; NadipalliPrabhakarRao; Nanduri, S.; Mullangi, R.; Srinivas, N. R. Concurrent Determination of Ezetimibe and Its Phase-I and II Metabolites by HPLC with UV Detection: Quantitative Application to Various In Vitro Metabolic Stability Studies and for Qualitative Estimation in Bile. J. Chromatogr. B 2007, 853(1–2), 88–96. https://doi.org/10.1016/j.jchromb.2007.02.053
    135. Nyavanandi, V. K.; Nadipalli, P.; Nanduri, S.; Iqbal, J.; A. Naidu. A Cross Metathesis Approach for the Synthesis of Tedanolide and 13D-Tedanolide: Stereo-Selective Synthesis of C3-C16 Segment. Tetrahedron Lett. 2007, 48(39), 6905–6911. https://doi.org/10.1016/j.tetlet.2007.07.156
    136. Nyavanandi, V. K.; Nanduri, S.; Vasudev, S.; Naidu, R.; Iqbal, J. Studies toward the Total Synthesis of Tedanolide: Stereo Selective Synthesis of the C(8)-C(17) Segment. Tetrahedron Lett. 2006, 47(37), 6667–6672. https://doi.org/10.1016/j.tetlet.2006.06.173
    137. Thunuguntla, S. S. R.; Nyavanandi, V. K.; Nanduri, S. A Facile Route for the Synthesis of Limonidilactone Analogues from Andrographolide. Tetrahedron Lett. 2004, 45(51), 9357–9360. https://doi.org/10.1016/j.tetlet.2004.10.135
    138. Nanduri, S.; Nyavanandi, V. K.; Thunuguntla, S. S. R.; Kasu, S.; Pallerla, M. K.; Ram, P. S.; Rajagopal, S.; Kumar, R. A.; Ramanujam, R.; Babu, J. M.; Vyas, K.; Devi, A. S.; Akella, V. Synthesis & Structure-Activity Relationships of Andrographolide Analogues as Novel Cytotoxic Agents. Bioorg. Med. Chem. Lett. 2004, 14(18), 4711–4717. https://doi.org/10.1016/j.bmcl.2004.06.090
    139. Nanduri, S.; Nyavanandi, V. K.; Thunuguntla, S. S. R.; Velisoju, M.; Kasu, S.; Rajagopal, S.; Kumar, Rajagopalan, R.; Iqbal, J. Novel Routes for the Generation of Structurally Diverse Labdane Diterpenes from Andrographolide. Tetrahedron Lett. 2004, 45(25), 4883–4886. https://doi.org/10.1016/j.tetlet.2004.04.142
    140. Kumar, R. A.; Sridevi, K.; Kumar, N. V.; Nanduri, S.; Rajagopal, S. Anticancer and Immunostimulatory Compounds from Andrographis paniculata. J. Ethnopharmacol. 2004, 92(2–3), 291–295. https://doi.org/10.1016/j.jep.2004.03.004
    141. Satyanarayana, C.; Deevi, D. S.; Rajagopalan, R.; Srinivas, N.; Rajagopal, S. DRF 3188: A Novel Semi-Synthetic Analog of Andrographolide: Cellular Response to MCF 7 Breast Cancer Cells. BMC Cancer 2004, 4(1), 26. https://doi.org/10.1186/1471-2407-4-26
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    143. Nanduri, S.; N.; Banstola, K. P. Neeflone, a New Tetranor Triterpenoid from the Flowers of Azadirachta indica A. Juss. Indian J. Chem. 1995, 34(11), 1019.
    144. Prabhakar, P.; Gandhidasan, R.; Raman, P. V.; Swami, N. K.; Nanduri, S. De-O-Methyl Racemosol: A Tetracyclic 2,2-Dimethylchroman from the Roots of Bauhinia Racemosa. Phytochemistry 1997, 36(3), 817–818. https://doi.org/10.1016/S0031-9422(00)89827-1
    145. Sripathi, S. K.; Gandhidasan, R.; Raman, P. V.; Krishnasamy, N. R.; Nanduri, S. First Occurrence of Xanthone and Isolation of a 6-Ketodehydro Rotenoid from Dalbergia sissoids. Phytochemistry 1998, 37(3), 911–912. https://doi.org/10.1016/S0031-9422(00)90384-4

    57 in peer reviewed journals
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    PATENTS

    54 filed (19 granted)
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    INVITED TALKS

    More than 30



    CONFERENCES / SEMINARS / WORKSHOPS ORGANIZED
    S.No Name of the Conference /Seminar / Workshop Year Role
    1 NIPER - PHARMA INDUSTRY MEET (SYNERGY - 2018) The Role of Academia in Strengthening the Indian Pharma 23rd August, 2018 Convener
    2 Workshop on Drug Discovery & Development; Concept, Clinic & Commercialization (D3C3): Module III 13th -14th April, 2018 Convener
    3 Workshop on Drug Discovery & Development; Concept, Clinic & Commercialization (D3C3): Module II 9th - 10th March, 2018 Convener
    4 Workshop on Drug Discovery & Development; Concept, Clinic & Commercialization (D3C3): Module I 16th - 17th February, 2018 Convener
    5 NIPER - Pharma Industry Meet (Role of Academia in Strengthening of Indian Pharma) 24th March 2017 Convener
    6 Conference on Drug Discovery & Development (Focus on Cancer & Diabetes) 16th & 17th March, 2017 Convener
    7 Conference on Innovations in Pharmaceutical Technologies & Workshop on GLP/GMP compliance 24th& 25th January 2017 Convener
    8 Conference on "Quality Management in Bulk Drug and Formulation Manufacturing" 12th& 13th Aug. 2016 Convener
    9 One day workshop on "Emerging Trends In Pharmaceutical Sciences" 9th July 2016 Convener
    10 Conference on Fostering Innovation in Pharmaceutical and IPR Management 21st -22nd March 2016 Convener
    11 Conference on Drug Discovery & Development (Global Scenario – Indian perspective) 20th -21st November 2015 Convener
    12 National Conference on Innovative Processes for Bulk Drugs (IPBD) 26th - 27th March 2015 Convener
    13 International Conference on Drugs for the Future: Infectious Diseases (DFID) 27th -28th March 2014 Convener


    ADDITIONAL RESPONSIBILITIES

    1. Coordinator, National Center for R & D Bulk Drugs Development
    2. Coordinator, Avishkaran, BioNEST Incubation Center at NIPER-Hyderabad
    3. Dean, NIPER-Hyderabad (March 2020- Aug 2021)
    4. Head of the Department, Department of Chemical Sciences, NIPER-Hyderabad (Aug 2020- Aug 2021)
    5. Convener, NIPER-JEE 2020 (Medical Devices)
    6. Head of the Department, Department of Process Chemistry, NIPER-Hyderabad (2014-2019)
    7. Placement Officer, NIPER-Hyderabad (2013-2018)



    ANY OTHER INFORMATION

    Developed 4 research labs for the chemical synthesis